R Loch Macdonald Selected Research

Nimodipine (Modus)

1/2022	Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage.
1/2021	Effect of Locally Delivered Nimodipine Microparticles on Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage.
1/2021	Neurovascular disease, diagnosis, and therapy: Subarachnoid hemorrhage and cerebral vasospasm.
12/2020	NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage.
1/2020	Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage.
12/2019	Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage.
1/2019	Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)].
1/2018	Neuroinflammation as a Target for Intervention in Subarachnoid Hemorrhage.
11/2017	Spontaneous subarachnoid haemorrhage.
1/2017	Response by Hänggi and Macdonald to Letter Regarding Article, "Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])".

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R Loch Macdonald Research Topics

Disease

87	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2022 - 05/2002
29	Infarction (Infarctions) 01/2022 - 11/2008
28	Aneurysm (Aneurysms) 01/2022 - 10/2003
23	Ischemia 01/2022 - 12/2004
22	Brain Ischemia (Cerebral Ischemia) 01/2022 - 09/2006
15	Cerebral Infarction 01/2021 - 04/2007
10	Intracranial Vasospasm 01/2022 - 05/2002
8	Hypotension (Low Blood Pressure) 01/2020 - 11/2008
8	Hypertension (High Blood Pressure) 05/2016 - 10/2003
7	Intracranial Aneurysm (Cerebral Aneurysm) 01/2020 - 11/2003
6	Rupture 08/2017 - 07/2012
5	Anemia 01/2018 - 11/2008
5	Brain Injuries (Brain Injury) 02/2017 - 12/2014
4	Stroke (Strokes) 01/2022 - 11/2012
4	Hemorrhage 01/2022 - 05/2003
4	Inflammation (Inflammations) 12/2016 - 05/2002
3	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2017 - 12/2014
3	Ischemic Stroke 12/2016 - 01/2009
3	Hematoma 09/2016 - 01/2011
3	Seizures (Absence Seizure) 01/2016 - 08/2013
2	Chronic Subdural Hematoma 04/2017 - 03/2016
2	Cerebral Hemorrhage 12/2016 - 03/2014
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 09/2016 - 01/2015
2	Bipolar Disorder (Manic Depressive Psychosis) 06/2016 - 01/2016
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2016 - 09/2014
2	Hydrocephalus (Hydrocephaly) 08/2015 - 10/2014
2	Atherosclerosis 06/2014 - 07/2012
2	Atrophy 07/2013 - 01/2013
2	Ruptured Aneurysm 03/2013 - 07/2011
2	Ganglion Cysts (Ganglion) 04/2011 - 07/2005
1	Carotid Stenosis (Carotid Artery Stenosis) 01/2022
1	Opioid-Related Disorders (Opiate Addiction) 01/2020
1	Intracranial Hypertension 12/2017
1	Subdural Hematoma (Subdural Hemorrhage) 04/2017
1	Unconsciousness (Loss of Consciousness) 02/2017
1	Headache (Headaches) 01/2017
1	Myocardial Infarction 01/2016
1	Hepatic Encephalopathy 01/2016
1	Pain (Aches) 12/2015

Drug/Important Bio-Agent (IBA)

31	clazosentanIBA 01/2022 - 11/2008
17	Nimodipine (Modus)FDA LinkGeneric 01/2022 - 10/2010
9	tirilazadIBA 01/2017 - 10/2003
7	Endothelin Receptor AntagonistsIBA 10/2019 - 11/2008
7	Pharmaceutical PreparationsIBA 01/2019 - 05/2003
5	Nicardipine (Dagan)FDA LinkGeneric 01/2022 - 05/2012
5	EG-1962IBA 12/2020 - 01/2015
5	Hemoglobins (Hemoglobin)IBA 04/2019 - 06/2002
4	Anticonvulsants (Antiepileptic Drugs)IBA 08/2013 - 08/2007
3	CollagenIBA 01/2020 - 03/2013
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2006
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022 - 07/2012
2	Heparin (Liquaemin)FDA LinkGeneric 01/2021 - 05/2003
2	Delayed-Action PreparationsIBA 01/2020 - 12/2019
2	SodiumIBA 01/2018 - 09/2017
2	Cytidine Triphosphate (CTP)IBA 08/2017 - 08/2015
2	AnticoagulantsIBA 04/2017 - 03/2016
2	Oxygen (Dioxygen)IBA 12/2016 - 01/2016
2	LithiumIBA 06/2016 - 01/2016
2	Angiotensin IIIBA 05/2016 - 07/2012
2	MagnesiumIBA 10/2014 - 06/2013
2	Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric 10/2014 - 01/2004
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2014 - 06/2010
2	Nicotine FDA Link 05/2014 - 10/2013
2	AlbuminsIBA 03/2014 - 03/2012
2	Neuroprotective AgentsIBA 03/2012 - 01/2009
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2011 - 02/2011
2	salicylhydroxamic acid (SHAM)IBA 04/2011 - 07/2005
2	Simvastatin (Zocor)FDA LinkGeneric 02/2011 - 01/2010
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2022
1	Opioid Analgesics (Opioids)IBA 01/2020
1	boldenone undecylenate (Equipoise)IBA 01/2020
1	HaptoglobinsIBA 04/2019
1	GlobinsIBA 04/2019
1	Mannitol (Osmitrol)FDA LinkGeneric 09/2017
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 04/2017
1	Indicators and Reagents (Reagents)IBA 02/2017
1	Explosive Agents (Explosives)IBA 01/2017
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/2016
1	Hemostatics (Antihemorrhagics)IBA 09/2016
1	AngiotensinsIBA 05/2016
1	Nitric Oxide Synthase (NO Synthase)IBA 05/2016
1	Fibrinolytic Agents (Antithrombotic Agents)IBA 03/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2015

Therapy/Procedure

22	Therapeutics 01/2022 - 09/2006
9	Critical Care (Surgical Intensive Care) 01/2021 - 11/2012
5	Surgical Instruments (Clip) 07/2018 - 01/2013
5	Craniotomy 10/2014 - 05/2003
5	Catheters 12/2013 - 10/2007
3	Endovascular Procedures 01/2017 - 11/2012
2	Decompressive Craniectomy 02/2018 - 12/2017
2	Activities of Daily Living (ADL) 03/2014 - 08/2010
2	Subacute Care 12/2013 - 10/2013
2	Intravenous Infusions 11/2012 - 01/2004
1	Intraventricular Injections 12/2019
1	Patient Admission (Patient Admissions) 03/2019
1	Erythrocyte Transfusion 01/2018
1	Length of Stay 02/2017
1	Injections 05/2016
1	Deep Sedation 12/2015